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KMID : 0617219910020010001
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Duksung Bulletin Phamaceutical Sciences
1991 Volume.2 No. 1 p.1 ~ p.22
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Pharmacological studies of butanol fraction from the rootbarks of Aralia elata
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Abstract
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The plant of Aralia elata (Araliaceae) is described to be used for treatment of diabetes, gastritis, neuralgegia and rheumatoid arthritis in oriental medicinal books.
This study is concerned with the effect on the gastritis and ulcer in rats and some general pharmacological action in rats. It was observed that the methanol extract of the rootbark of Aralia elata showed effectiveness in gastritis and pain in rats.
From the result obtained that the methanol extract exhibited antigastritic activity. Thus, It was fractionated into hexane, chloroform, ethylacetate and butanol, and further bioassays for the fractions resulted in potent activity in the butanol fraction. The fraction elicited analgesic effect by inhibition of writhing syndrome induced by acetic acid and by increment of pain-threshold in inflamed tail of mice. The fraction showed inhibition of HCl · ethanol and absolute ethanol induced gastritis and inhibition of Shay ulcer in rats. It also exhibited inhibition of gastric secretion in rats.
The fraction showed low acute toxicity, i.e., the minimum lethal dose was more than 5000 ㎎/㎏ in oral administration in rats and LD_50 was 740 ㎎/㎏ given subcutaneous by in rats.
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